Methyltetrazine-PEG4-amine HCl

Names

[ Name ]:
Methyltetrazine-PEG4-amine HCl

[Synonym ]:
2-[2-(2-{2-[4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy}ethoxy)ethoxy]ethanamine
Ethanamine, 2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]-
MFCD28334553

Biological Activity

[Description]:

Methyltetrazine-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
558.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₅N₅O₄

[ Molecular Weight ]:
363.411

[ Flash Point ]:
291.7±32.9 °C

[ Exact Mass ]:
363.190643

[ LogP ]:
-0.73

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.539

Methyltetrazine-PEG4-amine HCl

Names

Biological Activity

Chemical & Physical Properties

Related Compounds