Propargyl-PEG1-SS-PEG1-acid

Names

[ Name ]:
Propargyl-PEG1-SS-PEG1-acid

[Synonym ]:
3-(2-{[2-(2-Propyn-1-yloxy)ethyl]disulfanyl}ethoxy)propanoic acid
Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]-
MFCD28505557

Biological Activity

[Description]:

Propargyl-PEG1-SS-PEG1-acid is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
428.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆O₄S₂

[ Molecular Weight ]:
264.362

[ Flash Point ]:
213.1±28.7 °C

[ Exact Mass ]:
264.049011

[ LogP ]:
2.15

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.545

Propargyl-PEG1-SS-PEG1-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds