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Methylamino-PEG2-acid HCl

Names

[ CAS No. ]:
1807503-87-2

[ Name ]:
Methylamino-PEG2-acid HCl

[Synonym ]:
MFCD28155205
Propanoic acid, 3-[2-[2-(methylamino)ethoxy]ethoxy]-
3-{2-[2-(Methylamino)ethoxy]ethoxy}propanoic acid

Biological Activity

[Description]:

Methylamino-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
310.2±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H17NO4

[ Molecular Weight ]:
191.225

[ Flash Point ]:
141.4±23.7 °C

[ Exact Mass ]:
191.115753

[ LogP ]:
-0.90

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.453


Related Compounds