2-(t-Butoxycarbonylamido)-1,3-bis (t-butoxycarbonylethoxy)propane

Names

[ CAS No. ]:
1807503-91-8

[ Name ]:
2-(t-Butoxycarbonylamido)-1,3-bis (t-butoxycarbonylethoxy)propane

[Synonym ]:
MFCD28505566

Biological Activity

[Description]:

C-NH-Boc-C-Bis-(C-PEG1-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₄₁NO₈

[ Molecular Weight ]:
447.56

2-(t-Butoxycarbonylamido)-1,3-bis (t-butoxycarbonylethoxy)propane

Names

Biological Activity

Chemical & Physical Properties

Related Compounds