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Bromo-PEG2-acid

Names

[ CAS No. ]:
1807503-92-9

[ Name ]:
Bromo-PEG2-acid

[Synonym ]:
MFCD28122969
Propanoic acid, 3-[2-(2-bromoethoxy)ethoxy]-
3-[2-(2-Bromoethoxy)ethoxy]propanoic acid
Bromo-PEG3-acid

Biological Activity

[Description]:

Bromo-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
347.2±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H13BrO4

[ Molecular Weight ]:
241.080

[ Flash Point ]:
163.8±23.7 °C

[ Exact Mass ]:
239.999710

[ LogP ]:
0.34

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.486

Related Compounds