THP-SS-PEG1-Tos

Names

[ Name ]:
THP-SS-PEG1-Tos

[Synonym ]:
Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-, 4-methylbenzenesulfonate
2-{[2-(Tetrahydro-2H-pyran-2-yloxy)ethyl]disulfanyl}ethyl 4-methylbenzenesulfonate
MFCD28950768

Biological Activity

[Description]:

THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
539.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₄O₅S₃

[ Molecular Weight ]:
392.554

[ Flash Point ]:
280.0±30.1 °C

[ Exact Mass ]:
392.078583

[ LogP ]:
3.58

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.586

THP-SS-PEG1-Tos

Names

Biological Activity

Chemical & Physical Properties

Related Compounds