Mal-PEG5-PFP ester

Names

[ Name ]:
Mal-PEG5-PFP ester

[Synonym ]:
Pentafluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15-pentaoxaoctadecan-18-oate
3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,3,4,5,6-pentafluorophenyl ester
MFCD26127797

Biological Activity

[Description]:

Mal-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
594.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₆F₅NO₉

[ Molecular Weight ]:
555.446

[ Flash Point ]:
313.2±30.1 °C

[ Exact Mass ]:
555.152771

[ LogP ]:
0.93

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.492

Mal-PEG5-PFP ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds