DNP-PEG4-alcohol

Names

[ Name ]:
DNP-PEG4-alcohol

[Synonym ]:
MFCD28385460
Ethanol, 2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]-
2-[2-(2-{2-[(2,4-Dinitrophenyl)amino]ethoxy}ethoxy)ethoxy]ethanol

Biological Activity

[Description]:

DNP-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
557.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₁N₃O₈

[ Molecular Weight ]:
359.332

[ Flash Point ]:
290.7±30.1 °C

[ Exact Mass ]:
359.132874

[ LogP ]:
0.73

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.580

DNP-PEG4-alcohol

Names

Biological Activity

Chemical & Physical Properties

Related Compounds