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Bromoacetamido-PEG4-C2-Boc

Names

[ CAS No. ]:
1807521-00-1

[ Name ]:
Bromoacetamido-PEG4-C2-Boc

[Synonym ]:
MFCD28505519
2-Methyl-2-propanyl 1-bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
6,9,12,15-Tetraoxa-3-azaoctadecan-18-oic acid, 1-bromo-2-oxo-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Bromoacetamido-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Darren H. Wakefield, et al. Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
539.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H32BrNO7

[ Molecular Weight ]:
442.342

[ Flash Point ]:
280.0±30.1 °C

[ Exact Mass ]:
441.136200

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.477

[ Storage condition ]:
2-8°C

Related Compounds