Propargyl-PEG4-methylamine

Names

[ CAS No. ]:
1807530-11-5

[ Name ]:
Propargyl-PEG4-methylamine

[Synonym ]:
PROPARGYL-PEG4-MEA

Biological Activity

[Description]:

Propargyl-PEG4-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
317.1±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₃NO₄

[ Molecular Weight ]:
245.315

[ Flash Point ]:
136.2±14.6 °C

[ Exact Mass ]:
245.162704

[ LogP ]:
-0.87

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.452

Propargyl-PEG4-methylamine

Names

Biological Activity

Chemical & Physical Properties

Related Compounds