Hydroxy-PEG3-PFP ester

Names

[ Name ]:
Hydroxy-PEG3-PFP ester

[Synonym ]:
Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
MFCD26793756
Pentafluorophenyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate

Biological Activity

[Description]:

Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
440.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₇F₅O₆

[ Molecular Weight ]:
388.284

[ Flash Point ]:
220.1±28.7 °C

[ Exact Mass ]:
388.094543

[ LogP ]:
1.02

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.460

Hydroxy-PEG3-PFP ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds