<Suppliers Price>

3,4-Dibromo-Mal-PEG2-N-Boc

Names

[ CAS No. ]:
1807537-43-4

[ Name ]:
3,4-Dibromo-Mal-PEG2-N-Boc

[Synonym ]:
MFCD27635177
Carbamic acid, N-[2-[2-[2-(3,4-dibromo-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl (2-{2-[2-(3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl)carbamate

Biological Activity

[Description]:

3,4-Dibromo-Mal-PEG2-N-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
513.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H22Br2N2O6

[ Molecular Weight ]:
486.153

[ Flash Point ]:
264.1±30.1 °C

[ Exact Mass ]:
483.984436

[ LogP ]:
1.57

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.558

Related Compounds