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Mal-amido-PEG4-TFP ester

Names

[ CAS No. ]:
1807540-84-6

[ Name ]:
Mal-amido-PEG4-TFP ester

[Synonym ]:
MAL-AMIDO-PEG4-TFP ESTER

Biological Activity

[Description]:

Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
686.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H28F4N2O9

[ Molecular Weight ]:
564.481

[ Flash Point ]:
369.1±31.5 °C

[ Exact Mass ]:
564.173096

[ LogP ]:
0.39

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.507

Related Compounds