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Ald-Ph-amido-C2-PEG3-NH-Boc

Names

[ CAS No. ]:
1807540-87-9

[ Name ]:
Ald-Ph-amido-C2-PEG3-NH-Boc

[Synonym ]:
ALD-PH-PEG3-NH-BOC

Biological Activity

[Description]:

Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
614.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H32N2O7

[ Molecular Weight ]:
424.488

[ Flash Point ]:
325.7±31.5 °C

[ Exact Mass ]:
424.220947

[ LogP ]:
1.21

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.520

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds