Poloxin-2
Names
[ CAS No. ]:
1807690-39-6
[ Name ]:
Poloxin-2
Biological Activity
[Description]:
A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM; shows >10-fold selectivity over Plk2 PBD and Plk3 PBD; significantly improved potency and selectivity over Poloxin; induces mitotic arrest and apoptosis in cultured human tumor cells at low micromolar concentrations.
[References]
References 1. Scharow A, et al. ACS Chem Biol. 2015 Nov 20;10(11):2570-9. 2. Scharow A, et al. Chembiochem. 2016 Apr 15;17(8):759-67. View Related Products by Target Polo-like Kinase (PLK)
Chemical & Physical Properties
[ Molecular Formula ]:
C16H15NO3
[ Molecular Weight ]:
269.3