GPA 512

The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes; increases the plasma exposure of the active parent compound 20-fold compared to Galiellalactone; significantly reduces tumor growth in DU145 xenograft tumors.

References 1. Escobar Z, et al. J Med Chem. 2016 May 26;59(10):4551-62. View Related Products by Target STAT