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SMAP-2

Names

[ CAS No. ]:
1809068-70-9

[ Name ]:
SMAP-2

Biological Activity

[Description]:

SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

PP2A[1]


[References]

[1]. Sangodkar J, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017 Jun 1;127(6):2081-2090.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H27F3N2O4S

[ Molecular Weight ]:
532.57

Related Compounds