S-acetyl-PEG6-Tos

Names

[ Name ]:
S-acetyl-PEG6-Tos

[Synonym ]:
S-(17-{[(4-Methylphenyl)sulfonyl]oxy}-3,6,9,12,15-pentaoxaheptadec-1-yl) ethanethioate
MFCD22201540
Ethanethioic acid, S-[17-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15-pentaoxaheptadec-1-yl] ester

Biological Activity

[Description]:

S-acetyl-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
591.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₄O₉S₂

[ Molecular Weight ]:
494.619

[ Flash Point ]:
311.2±30.1 °C

[ Exact Mass ]:
494.164429

[ LogP ]:
0.69

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.513

S-acetyl-PEG6-Tos

Names

Biological Activity

Chemical & Physical Properties

Related Compounds