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S-acetyl-PEG4-Boc

Names

[ CAS No. ]:
1818294-26-6

[ Name ]:
S-acetyl-PEG4-Boc

[Synonym ]:
2-Methyl-2-propanyl 2-oxo-6,9,12,15-tetraoxa-3-thiaoctadecan-18-oate
MFCD22574785
6,9,12,15-Tetraoxa-3-thiaoctadecan-18-oic acid, 2-oxo-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

S-acetyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
452.0±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H32O7S

[ Molecular Weight ]:
380.497

[ Flash Point ]:
207.2±15.4 °C

[ Exact Mass ]:
380.186859

[ LogP ]:
1.16

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.471


Related Compounds