<Suppliers Price>

Fluorescein-PEG6- NHS ester

Names

[ CAS No. ]:
1818294-35-7

[ Name ]:
Fluorescein-PEG6- NHS ester

[Synonym ]:
5-[({21-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxahenicos-1-yl}carbamothioyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
Benzoic acid, 5-[[23-[(2,5-dioxo-1-pyrrolidinyl)oxy]-23-oxo-1-thioxo-5,8,11,14,17,20-hexaoxa-2-azatricos-1-yl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
MFCD23726632

Biological Activity

[Description]:

Fluorescein-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
976.2±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C40H45N3O15S

[ Molecular Weight ]:
839.861

[ Flash Point ]:
544.2±37.1 °C

[ Exact Mass ]:
839.257141

[ LogP ]:
-1.08

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.649

Related Compounds