<Suppliers Price>

MC-VA-PABC-MMAE

Names

[ CAS No. ]:
1818864-51-5

[ Name ]:
MC-VA-PABC-MMAE

Biological Activity

[Description]:

MC-VA-PABC-MMAE is a drug-linker conjugate for ADC. MC-VA-PABC-MMAE contains the ADCs linker (peptide MC-VA-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1][2].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Auristatin


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Wang Y, et al. Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766.

[2]. Cazzamalli S, et al. Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma. J Control Release. 2017 Jan 28;246:39-45.

Chemical & Physical Properties

[ Molecular Formula ]:
C65H99N9O14

[ Molecular Weight ]:
1230.53

Related Compounds