Ribocil B

Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN) with a KD of 6.6 nM.

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

KD: 6.6 nM (FMN)[1]

Ribocil-B (S-isomer) is a tight binder to the FMN riboswitch and ribocil-A (R-isomer) does not similarly interact and display antibiotic activity[1].

[1]. John A. Howe, et al. Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch.

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