S07-2005 (racemic)

Names

[ CAS No. ]:
1826337-40-9

[ Name ]:
S07-2005 (racemic)

Biological Activity

[Description]:

S07-2005 racemic is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. S07-2005 racemic has potential as a chemotherapeutic potentiator for cancer drug resistance[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 2.88 ± 1.10 μM (AKR1C1), 0.13 ± 0.03 μM (AKR1C3), 0.75 ± 0.32 μM (AKR1C4)[1]


[References]

[1]. Siyu He, et al. Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance. ACS Med. Chem. Lett. Jun 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23NO6

[ Molecular Weight ]:
373.40

Related Compounds