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PF-06456384 trihydrochloride

Names

[ CAS No. ]:
1834610-75-1

[ Name ]:
PF-06456384 trihydrochloride

[Synonym ]:
3-Cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide trihydrochloride
Benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-, hydrochloride (1:3)
Benzenesulfonamide, 3-cyano-4-[[3-[2-[[[2-(4-piperidinyl)ethyl]amino]methyl]-4-pyridinyl]-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy]-N-1,2,4-thiadiazol-5-yl-
3-Cyano-4-({3-[2-({[2-(4-piperidinyl)ethyl]amino}methyl)-4-pyridinyl]-3'-(trifluoromethyl)-4-biphenylyl}oxy)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Biological Activity

[Description]:

PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 trihydrochloride can be used for parkinson's disease (PD) research[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> LRRK2
Research Areas >> Neurological Disease

[References]

[1]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
789.8±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C35H32F3N7O3S2

[ Molecular Weight ]:
719.799

[ Flash Point ]:
431.4±35.7 °C

[ Exact Mass ]:
719.195984

[ LogP ]:
6.95

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.666

Related Compounds