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hDHODH-IN-2

Names

[ CAS No. ]:
183946-00-1

[ Name ]:
hDHODH-IN-2

Biological Activity

[Description]:

hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
Research Areas >> Inflammation/Immunology

[In Vitro]

hDHODH-IN-2 (Compound 42) inhibits rat and mouse DHODH with log(1/IC50) values of 5.83 and 5.80, respectively in self-organizing molecular field analysis (SOMFA)[1].

[References]

[1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.

[2]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H16N2O2

[ Molecular Weight ]:
304.34

Related Compounds