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Taxinine B

Names

[ CAS No. ]:
18457-44-8

[ Name ]:
Taxinine B

[Synonym ]:
2-Propenoic acid, 3-phenyl-, (1S,3S,4aR,5R,6R,11R,12R,12aS)-1,5,11,12-tetrakis(acetyloxy)-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-9,12a,13,13-tetramethyl-4-methylene-8-oxo-6,10-methanobenzocyclodecen-3-yl ester, (2E)-
(2α,5α,7β,9α,10β)-2,7,9,10-tetrakis(acetyloxy)-13-oxotaxa-4(20),11-dien-5-yl (2E)-3-phenylprop-2-enoate
(2α,5α,7β,9α,10β)-2,7,9,10-Tetraacetoxy-13-oxotaxa-4(20),11-dien-5-yl (2E)-3-phenylacrylate

Biological Activity

[Description]:

Taxinine B is a taxoid that can be isolated from Japanese Yew Taxus Cuspid. Taxinine B inhibits CaCl2-induced depolymerization of microtubule. Taxinine B is useful for overcoming multidrug resistance in tumor cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Juníchi Kobayashi, et al. Taxuspines A ∼ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells. Tetrahedron. 1994. 50 (25), 7401-7416.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
705.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C37H44O11

[ Molecular Weight ]:
664.74

[ Flash Point ]:
286.7±32.9 °C

[ Exact Mass ]:
664.288391

[ PSA ]:
148.57000

[ LogP ]:
5.60

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.558

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds