Pregnanediol 3-glucuronide

Names

[ Name ]:
Pregnanediol 3-glucuronide

[Synonym ]:
3alpha,20alpha-dihydroxy-5beta-pregnane 3-glucuronide

Biological Activity

[Description]:

Pregnanediol 3-glucuronide is the major terminal metabolite of progesterone, playing an important role in physiological processes, such as the female menstrual cycle, pregnancy (supports gestation), embryogenesis and maternal immune response of humans and other species[1].

[Related Catalog]:

Research Areas >> Endocrinology

[Target]

Human Endogenous Metabolite

[References]

[1]. Chen J, et al. Quantitation of serum pregnanediol-3-glucuronide level in different endocrine statuses by LC-MS/MS. J Pharm Biomed Anal. 2020;184:113171.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
666.4ºC at 760mmHg

[ Melting Point ]:
>94°C (dec.) (lit.)

[ Molecular Formula ]:
C₂₇H₄₄O₈

[ Molecular Weight ]:
496.63300

[ Flash Point ]:
217.2ºC

[ Exact Mass ]:
496.30400

[ PSA ]:
136.68000

[ LogP ]:
2.30350

[ Vapour Pressure ]:
1.34E-20mmHg at 25°C

[ Index of Refraction ]:
1.587

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Progesterone, pregnanediol-3-glucuronide, relaxin and oestrone sulphate concentrations in saliva, milk and urine of female alpacas (Vicugna pacos) and their application in pregnancy diagnosis.

Vet. Rec. 171(8) , 195, (2012)

The pregnancy-associated hormones, progesterone (P4), pregnanediol-3-glucuronide (PdG), relaxin (RLN) and oestrone sulphate (E1S) in plasma, saliva, milk and urine of alpacas were measured in order to...

Factors related to declining luteal function in women during the menopausal transition.

J. Clin. Endocrinol. Metab. 93(5) , 1711-21, (2008)

Reproductive hormones are incompletely characterized during the menopause transition (MT).Increased anovulation and decreased progesterone accompany progress through the MT.The Daily Hormone Study (DH...

Describing ovarian cycles, pregnancy characteristics, and the use of contraception in female white-faced marmosets, Callithrix geoffroyi.

Am. J. Primatol. 74(11) , 1044-53, (2012)

Endocrine data and characteristics of nonconceptive ovarian cycling and pregnancy are limited within the genus Callithrix to the common marmoset (C. jacchus) and Wied's black tufted-ear marmoset (C. k...