Azido-PEG3-maleimide

Names

[ Name ]:
Azido-PEG3-maleimide

[Synonym ]:
(1Z)-N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanimidic acid
1H-Pyrrole-1-propanimidic acid, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo-

Biological Activity

[Description]:

Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Deshmukh AA, et al. Detection of Protease Activity by Fluorescent Peptide Zymography. J Vis Exp. 2019 Jan 20;(143).

[2]. Allo B, et al. Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjug Chem. 2018 Jun 20;29(6):2028-2038.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₃N₅O₆

[ Molecular Weight ]:
369.373

[ Exact Mass ]:
369.164825

[ LogP ]:
-0.60

Azido-PEG3-maleimide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds