Hydroxy-PEG3-(CH2)2-Boc

Names

[ Name ]:
Hydroxy-PEG3-(CH2)2-Boc

[Synonym ]:
Hydroxy-PEG3-t-butyl ester
12-hydroxy-4,7,10-trioxadodecanoic acid tert-butyl ester
tert-Butyl triethylene glycol-O-propionate
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate

Biological Activity

[Description]:

Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.

Chemical & Physical Properties

[ Density]:
1.057g/cm3

[ Boiling Point ]:
365.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₆O₆

[ Molecular Weight ]:
278.34200

[ Flash Point ]:
125.2ºC

[ Exact Mass ]:
278.17300

[ PSA ]:
74.22000

[ LogP ]:
0.76030

[ Vapour Pressure ]:
7.78E-07mmHg at 25°C

[ Index of Refraction ]:
1.45

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Angew. Chem. Int. Ed. Engl. 113 , 379, (2001)