GPI-1485

Names

[ Name ]:
GPI-1485

[Synonym ]:
(S)-methyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate
UNII-0709BVY57W
(2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidincarboxylic acid
GPI-1485
(2S)-1-(1,2-dioxo-3,3-dimethylpentyl)-2-pyrrolidine-carboxylic acid

Biological Activity

[Description]:

GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

GPI-1485 (GM1485; 100 μM) induces cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF)[1]. Cell Viability Assay[1] Cell Line: Normal human dermal fibroblasts (NHDF)[1] Concentration: 100 μM Incubation Time: Result: Induced cellular reprogramming and neural cell induction.

[In Vivo]

GPI-1485 (GM1485; 5 mg/kg; intraperitoneal injection; 6-week period of daily) improves long-term neurological recovery in rats[1]. Animal Model: Adult male Wistar rats, weighing 250-300 g[1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; daily; for a total of 42 days Result: Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats.

[References]

[1]. Andrew F Ducruet , et al. GM1485, a Nonimmunosuppressive Immunophilin Ligand, Promotes Neurofunctional Improvement and Neural Regeneration Following Stroke. J Neurosci Res. 2012 Jul;90(7):1413-23.

Chemical & Physical Properties

[ Density]:
1.189 g/cm3

[ Boiling Point ]:
386.198ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₉NO₄

[ Molecular Weight ]:
241.28400

[ Flash Point ]:
187.366ºC

[ Exact Mass ]:
241.13100

[ PSA ]:
74.68000

[ LogP ]:
1.00520

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%