Fmoc-N-PEG7-acid

Names

[ Name ]:
Fmoc-N-PEG7-acid

[Synonym ]:
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25-octaoxa-4-azaoctacosan-28-oic acid
2,7,10,13,16,19,22,25-Octaoxa-4-azaoctacosan-28-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-

Biological Activity

[Description]:

Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
758.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₄₅NO₁₁

[ Molecular Weight ]:
619.700

[ Flash Point ]:
412.2±32.9 °C

[ Exact Mass ]:
619.299255

[ LogP ]:
1.23

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.534

Fmoc-N-PEG7-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds