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PF-06737007

Names

[ CAS No. ]:
1863905-38-7

[ Name ]:
PF-06737007

Biological Activity

[Description]:

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor
Research Areas >> Neurological Disease

[Target]

TrkA:7.7 nM (IC50, in cell-based assays)

TrkB:15 nM (IC50, in cell-based assays)

TrkC:3.9 nM (IC50, in cell-based assays)


[In Vitro]

PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM[1].

[References]

[1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H28F4N2O6

[ Molecular Weight ]:
528.49

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds