Clomethiazole Edisylate
Names
[ CAS No. ]:
1867-58-9
[ Name ]:
Clomethiazole Edisylate
[Synonym ]:
clomethiazole
chlormethiazole ethanedisulfonate
ethane-1,2-disulphonic acid,compound with 5-(2-chloroethyl)-4-methylthiazole (1:2)
clomethiazole edisylate
chlormethiazole
bis-5-(2-chloroethyl)-4-methylthiazole edisilate
Clomethiazole ethanedisulfonate
Heminevrin
Chemical & Physical Properties
[ Density]:
1.218g/cm3
[ Boiling Point ]:
245.8ºC at 760mmHg
[ Molecular Formula ]:
C14H22Cl2N2O6S4
[ Molecular Weight ]:
513.50000
[ Flash Point ]:
102.4ºC
[ Exact Mass ]:
511.97400
[ PSA ]:
207.76000
[ LogP ]:
5.38920
[ Vapour Pressure ]:
1.07E-23mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KI3280000
- CAS REGISTRY NUMBER :
- 1867-58-9
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C6-H8-Cl-N-S.1/2C2-H6-O6-S2
- MOLECULAR WEIGHT :
- 256.74
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1560 mg/kg/4D-C
- TOXIC EFFECTS :
- Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- Volume(issue)/page/year: 10,315,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 835 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 4,269,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 380 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,657,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 620 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 4,269,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 4,269,1967
Safety Information
[ HS Code ]:
2934100090
Customs
[ HS Code ]: 2934100090
[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%