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RA-2

Names

[ CAS No. ]:
1867107-62-7

[ Name ]:
RA-2

[Synonym ]:
1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate
RA-2
1,3-Phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate)
Benzoic acid, 3-fluoro-4-hydroxy-, 1,3-phenylenebis(methylene) ester
1,1'-[1,3-Phenylenebis(methylene)]-3-fluoro-4-hydroxy-benzoic acid ester

Biological Activity

[Description]:

RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Oliván-Viguera A, et al. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol Pharmacol. 2015;87(2):338-348.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
590.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H16F2O6

[ Molecular Weight ]:
414.356

[ Flash Point ]:
310.9±30.1 °C

[ Exact Mass ]:
414.091492

[ LogP ]:
5.91

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.620

Related Compounds