Myristoyl coenzyme A lithium salt

Names

[ Name ]:
Myristoyl coenzyme A lithium salt

Biological Activity

[Description]:

Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

[Target]

Human Endogenous Metabolite

[References]

[1]. Raju RV, et al. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Mol Cell Biochem. 1996 May 24;158(2):107-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₅₈Li₄N₇O₁₇P₃S

[ Molecular Weight ]:
1001.62

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Functional significance of myristoyl moiety in N-myristoyl proteins.

Meth. Enzymol. 250 , 405, (1995)

Fatty acid elongation in yeast--biochemical characteristics of the enzyme system and isolation of elongation-defective mutants.

Eur. J. Biochem. 252 , 477-485, (1998)

Elongation of long-chain fatty acids was investigated in yeast mutants lacking endogenous de novo fatty acid synthesis. In this background, in vitro fatty acid elongation was dependent strictly on the...

Modification of GTP-activated calcium translocation by fatty acyl-CoA esters. Evidence for a GTP-induced prefusion event.

J. Biol. Chem. 269 , 31607, (1994)

A sensitive and specific GTP-activated Ca2+ translocation process induces rapid Ca2+ movements within cells and appears to reflect G protein-induced membrane fusion or junctional communication between...