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Fmoc-Hyp(Bom)-OH

Names

[ CAS No. ]:
187223-15-0

[ Name ]:
Fmoc-Hyp(Bom)-OH

[Synonym ]:
1,2-Pyrrolidinedicarboxylic acid, 4-[[[[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]amino]carbonyl]oxy]-, 1-(9H-fluoren-9-ylmethyl) ester, (2S,4R)-
1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-({[2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)ethyl]carbamoyl}oxy)proline
Fmoc-(2S,4R)-Pro(4-OCO-NH-CH2-CH2-NH-Boc)-OH
1,2-Pyrrolidinedicarboxylic acid, 4-[[[[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]amino]carbonyl]oxy]-, 1-(9H-fluoren-9-ylmethyl) ester
(4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-({[2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)ethyl]carbamoyl}oxy)-L-proline
Fmoc-Hyp(Bcc)-OH
Fmoc-(2S,4R)-(4-OCO-NH-CH2-CH2-NH-Boc)-Pro-OH
(2S,4R)-4-[[[[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]amino]carbonyl]oxy]-1,2-pyrrolidinedicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester
Fmoc-Hyp(Bom)-OH

Biological Activity

[Description]:

Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]<

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.35±0.1 g/cm3

[ Boiling Point ]:
749.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H33N3O8

[ Molecular Weight ]:
539.577

[ Flash Point ]:
406.8±32.9 °C

[ Exact Mass ]:
539.226746

[ PSA ]:
143.50000

[ LogP ]:
3.54

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.620

[ Water Solubility ]:
Insuluble (1.5E-3 g/L) (25 ºC)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds