Dacisteine

Names

[ Name ]:
Dacisteine

[Synonym ]:
Dacisteina
Dacisteine
S,N-diacetylcysteine
N,S-Diacetyl
Acetylcysteine impurity D
N,S-diacetyl-D,L-cysteine
N,S-diacetyl-L-cysteine
N,S-Diacetylcysteine
Dacisteinum
N,S-diacetil-L-cisteina

Biological Activity

[Description]:

Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC50 value of 1000 μM[1]. Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation[2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

IC50: 1000 μM (NDM-1)[1]

[In Vivo]

Dacisteine is a preparing agent for treating or preventing cardiovascular and cerebrovascular diseases caused by platelet aggregation.

[References]

[1]. Cui-Gai Bai1, et al. Cysteine and Its Derivatives as New Delhi Metallo-beta-lactamase-1 Inhibitors. Current Enzyme Inhibition, 2015, 11, 46-57

[2]. FanKe, et al.Application of compound of thioether acid structure in preparing anti-platelet aggregation drugs. Patent WO2019007015A1.

Chemical & Physical Properties

[ Density]:
1.314g/cm3

[ Boiling Point ]:
446.8ºC at 760 mmHg

[ Melting Point ]:
114-116°C

[ Molecular Formula ]:
C₇H₁₁NO₄S

[ Molecular Weight ]:
205.23200

[ Flash Point ]:
224ºC

[ Exact Mass ]:
205.04100

[ PSA ]:
108.77000

[ LogP ]:
0.24630

[ Vapour Pressure ]:
3.13E-09mmHg at 25°C

[ Index of Refraction ]:
1.522

[ Storage condition ]:
Refrigerator

Safety Information

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Formation of the thioester, N,S-diacetylcysteine, from acetaldehyde and N,N'diacetylcystine in aqueous solution with ultraviolet light.

J. Mol. Evol. 17(2) , 103-7, (1981)

The thioester, N,S-diacetylcysteine, is formed during the illumination of phosphate buffered (pH 7.0) aqueous solutions of acetaldehyde and N,N'-diacetylcystine with ultraviolet light. The yield of N,...