DD1

Names

[ Name ]:
DD1

[Synonym ]:
3,3'-Diamino-4'-methoxyflavone
DD1

Biological Activity

[Description]:

DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)

[In Vitro]

DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells[1]. DD1 induces cell cycle arrest at G2/M phase and apoptosis[1]. DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation[1]. DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates[1].

[References]

[1]. Marion Piedfer, et al. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochim Biophys Acta. 2013 Jun;1833(6):1316-28.

Chemical & Physical Properties

[ Density]:
1.337g/cm3

[ Boiling Point ]:
479.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂O₃

[ Molecular Weight ]:
282.29400

[ Flash Point ]:
233.6ºC

[ Exact Mass ]:
282.10000

[ PSA ]:
91.48000

[ LogP ]:
3.79540

[ Vapour Pressure ]:
2.4E-09mmHg at 25°C

[ Index of Refraction ]:
1.667

[ Storage condition ]:
-20°C

DD1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds