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(R)-Lercanidipine Hydrochloride

Names

[ CAS No. ]:
187731-34-6

[ Name ]:
(R)-Lercanidipine Hydrochloride

[Synonym ]:
(4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester Hydrochloride
UNII-OA8TFX68PE component WMFYOYKPJLRMJI-MGDILKBHSA-N
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester, (4R)-, hydrochloride (1:1)
1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methyl-2-propanyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)
(R)-Lercanidipine Hydrochloride

Biological Activity

[Description]:

(R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a calcium channel blocker[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cardiovascular Disease

[Target]

calcium channel[1]


[References]

[1]. Wirtz S,et al. Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine. Br J Pharmacol. 2004 May;142(2):275-84.

Chemical & Physical Properties

[ Melting Point ]:
175-177ºC

[ Molecular Formula ]:
C36H42ClN3O6

[ Molecular Weight ]:
648.188

[ Exact Mass ]:
647.276184

[ PSA ]:
113.69000

[ LogP ]:
8.13240

Related Compounds