Arachidonoyl serotonin
Names
[ CAS No. ]:
187947-37-1
[ Name ]:
Arachidonoyl serotonin
[Synonym ]:
(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-icosatetraenamide
Arachidonoyl serotonin
AA-5-HT N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenamide
(5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide
Arachidonyl serotonin,N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
5,8,11,14-Eicosatetraenamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, (5Z,8Z,11Z,14Z)-
Arachidonyl serotonin
N-Arachidonoylserotonin
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 1~12 µM (FAAH), 70~100 nM (TRPV1 channels)[1]
[References]
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
680.5±55.0 °C at 760 mmHg
[ Molecular Formula ]:
C30H42N2O2
[ Molecular Weight ]:
462.667
[ Flash Point ]:
365.3±31.5 °C
[ Exact Mass ]:
462.324615
[ PSA ]:
65.12000
[ LogP ]:
7.16
[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C
[ Index of Refraction ]:
1.574
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
Articles
Basic Clin Pharmacol Toxicol. 115(4) , 330-4, (2014)
Selective blockade of anandamide hydrolysis, through the inhibition of the FAAH enzyme, has anticonvulsant effects, which are mediated by CB1 receptors. Anandamide, however, also activates TRPV1 chann...
The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.Pharmacol. Res. 61 , 537-46, (2010)
Given that the pharmacological or genetic inactivation of fatty acid amide hydrolase (FAAH) counteracts pain and inflammation, and on the basis of the established involvement of transient receptor pot...
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats de Novellis, V., et al.Mol. Pain 17 , 7, (2011)