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WKYMVm

Names

[ CAS No. ]:
187986-17-0

[ Name ]:
WKYMVm

[Synonym ]:
M.W. 856.11 C41H61N9O7S2
H-TRP-LYS-TYR-MET-VAL-D-MET-NH2 TRIFLUOROACETATE
WKYMVMaMide,W-Peptide
H-Ala-Val-Thr-Tyr-Ser-Arg-Ser-Arg-Tyr-Leu-Glu-Cys-OH
Tryptophanyl-lysinyl-tyrosinyl-methionyl-valinyl-D-methionine
WKYMVMAMIDE TRIFLUOROACETATE

Biological Activity

[Description]:

WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

FPR1, FPRL1[1], FPRL2[2]


[References]

[1]. Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276(24):21585-93.

[2]. Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56(5):470-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C41H61N9O7S2

[ Molecular Weight ]:
856.11

[ Exact Mass ]:
856.39800

[ PSA ]:
321.46000

[ LogP ]:
5.14090

Related Compounds