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JAK1/TYK2-IN-1

Names

[ CAS No. ]:
1883300-48-8

[ Name ]:
JAK1/TYK2-IN-1

Biological Activity

[Description]:

JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

[References]

[1]. Fensome A, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28(10):115481.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₀F₃N₇O

[ Molecular Weight ]:
407.39

Related Compounds