UPCDC30245

Names

[ Name ]:
UPCDC30245

[Synonym ]:
1-[3-(5-Fluoro-1H-indol-2-yl)phenyl]-N-[2-(4-isopropyl-1-piperazinyl)ethyl]-4-piperidinamine
1-Piperazineethanamine, N-[1-[3-(5-fluoro-1H-indol-2-yl)phenyl]-4-piperidinyl]-4-(1-methylethyl)-
1-(3-(5-Fluoro-1H-indol-2-yl)phenyl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)piperidin-4-amine
UPCDC30245
1-(3-(5-Fluoro-1h-Indol-2-Yl)phenyl)piperidin-4-Yl)(2-(4-Isopropyl-Piperazin1-Yl)ethyl)-Carbamate

Biological Activity

[Description]:

UPCDC30245 is an allosteric inhibitor of AAA ATPase p97 with IC50 of 27 nM, binds at the junction between the D1 and D2 domains of p97.

[References]

References 1. Segura-Cabrera A, et al. Sci Rep. 2017 Mar 21;7:44912. 2. Banerjee S, et al. Science. 2016 Feb 19;351(6275):871-5. View Related Products by Target p97/VCP

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
647.6±55.0 °C at 760 mmHg

[ Melting Point ]:
647.6 °C

[ Molecular Formula ]:
C₂₈H₃₈FN₅

[ Molecular Weight ]:
463.633

[ Flash Point ]:
345.4±31.5 °C

[ Exact Mass ]:
463.311127

[ LogP ]:
4.56

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.641

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi