4-Ethynyl-L-phenylalanine hydrochloride
Names
[ CAS No. ]:
188640-63-3
[ Name ]:
4-Ethynyl-L-phenylalanine hydrochloride
Biological Activity
[Description]:
4-Ethynyl-L-phenylalanine hydrochloride is a selective, reversible, potent and competitive inhibitor of tryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine hydrochloride is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6 μM. 4-Ethynyl-L-phenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1].
[Related Catalog]:
[Target]
Ki: 32.6 μM (TPH)[1]
[In Vivo]
4-Ethynyl-L-phenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1]. 4-Ethynyl-L-phenylalanine hydrochloride is not inhibiting the aromatic amino acid decarboxylase[1]. 4-Ethynyl-L-phenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors[1]. Animal Model: Male Sprague-Dawley rats (200 g)[1] Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C11H12ClNO2
[ Molecular Weight ]:
225.67