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Hydroxytanshinone IIA

Names

[ CAS No. ]:
18887-18-8

[ Name ]:
Hydroxytanshinone IIA

[Synonym ]:
9-Hydroxy-1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione
Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-9-hydroxy-1,6,6-trimethyl-

Biological Activity

[Description]:

Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[References]

[1]. Peng Li, et al. Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(5):815-22.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
523.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H18O4

[ Molecular Weight ]:
310.344

[ Flash Point ]:
270.4±30.1 °C

[ Exact Mass ]:
310.120514

[ LogP ]:
3.62

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.611

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds