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TBK1/IKKε-IN-1(compound 1)

Names

[ CAS No. ]:
1893397-65-3

[ Name ]:
TBK1/IKKε-IN-1(compound 1)

Biological Activity

[Description]:

TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Research Areas >> Cancer

[Target]

IC50: 1 nM (TBK1), 5.6 nM (IKKε)[1].

[References]

[1]. Jenkins RW, et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018 Feb;8(2):196-215.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₁N₇O₃

[ Molecular Weight ]:
513.59

Related Compounds