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19,20-Epoxycytochalasin C

Names

[ CAS No. ]:
189351-79-9

[ Name ]:
19,20-Epoxycytochalasin C

[Synonym ]:
19,20-Epoxycytochalasin C
3H-Oxireno[9,10]cycloundec[1,2-d]isoindole-3,13(4H)-dione, 14-(acetyloxy)-1a,2,5,7a,8,10a,11,12,14,14a-decahydro-2,8-dihydroxy-2,4,9,10-tetramethyl-11-(phenylmethyl)-, (1aR,2R,4S,6E,7aR,8S,10aR,11S,13aR,14aS)-
(1aR,2R,4S,6E,7aR,8S,10aR,11S,13aR,14aS)-11-Benzyl-2,8-dihydroxy-2,4,9,10-tetramethyl-3,13-dioxo-2,3,4,5,7a,8,10a,11,12,13,14,14a-dodecahydro-1aH-oxireno[9,10]cycloundeca[1,2-d]isoindol-14-yl acetate

Biological Activity

[Description]:

19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection

[Target]

Microbial Metabolite


[In Vitro]

19,20-Epoxycytochalasin C shows moderate toxicity to cell line SK-MEL with an IC50 of 8.02 µM[1].

[In Vivo]

Evaluation of in vivo antimalarial activity of 19,20-Epoxycytochalasin C in a mouse model at 100 mg/kg dose shows that this compound has weak suppressive antiplasmodial activity and is toxic to animals[1].

[References]

[1]. Mallika Kumarihamy, et al. Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf. Molecules. 2019 Feb 21;24(4):777.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
737.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H37NO7

[ Molecular Weight ]:
523.617

[ Flash Point ]:
399.7±32.9 °C

[ Exact Mass ]:
523.257019

[ LogP ]:
3.64

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.610

Related Compounds