PI3K-IN-16
Names
[ CAS No. ]:
1895876-81-9
[ Name ]:
PI3K-IN-16
Biological Activity
[Description]:
PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively; exhibits no significant activity on PI3Kα; shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft.
[References]
References 1. Barlaam B, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23. View Related Products by Target PI3K
Chemical & Physical Properties
[ Molecular Formula ]:
C25H26FN3O5
[ Molecular Weight ]:
467.497