Ac-DEVD-pNA

Names

[ Name ]:
Ac-DEVD-pNA

Biological Activity

[Description]:

Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases.

[In Vitro]

Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases. It is also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10. The sequence is based on PARP (poly(ADPribose) polymerase) cleavage site Asp216 for caspase-3. Cleavage is monitored colorimetrically at 405nm.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₄N₆O₁₃

[ Molecular Weight ]:
638.5

Related Compounds

AC-DEVD-PNA
Ac-DEVD-CHO
acetyl-Asp-Glu-Val-Asp-fluoromethyl-ketone
Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt
Ac-Asp-Glu-Val-Asp-AFC
Ac-Asp-Glu-Val-Asp-AMC ammonium salt
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