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(2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol

Names

[ CAS No. ]:
190315-43-6

[ Name ]:
(2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol

[Synonym ]:
(2R,3S,4R)-2-Hydroxymethyl-tetrahydro-thiophene-3,4-diol
1,4-anhydro-4-thio-D-ribose
(+)-1-deoxy-4-thio-D-ribose

Biological Activity

[Description]:

(2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C5H10O3S

[ Molecular Weight ]:
150.20

[ Exact Mass ]:
150.03500

[ PSA ]:
85.99000

Related Compounds